Frances McDormand – Mildred
Woody Harrelson – Willoughby
Sam Rockwell – Dixon
Peter Dinklage – James
John Hawkes – Charlie
Samara Weaving – Penelope, Charlie’s girlfriend
Caleb Landry Jones – Red Welby
Željko Ivanek – Desk Sergeant
Abbie Cornish – Anne, Willoughby’s wife
Lucas Hedges – Robbie, Mildred’s son
Kathryn Newton – Angela, Mildred’s daughter
Brendan Sexton III – Frightening crop-haired guy
Jerry Winsett – Geoffrey, the dentist
Nick Searcy – Father Montgomery
Clarke Peters – Abercrombie, Willoughby’s replacement
Amanda Warren – Denise, Mildred’s coworker
Kerry Condon – Pamela, Red’s secretary
Darrell Britt-Gibson – Jerome
Malaya Rivera Drew – Gabriella
Jason Miller – Gabriella’s Cameraman
Sandy Martin – Momma Dixon
Christopher Berry – Tony
Cowboy – Officer Swanson
Lawrence Turner – Tony
Riya May Atwood – Polly, Willoughby’s daughter
Selah Atwood – Jane, Willoughby’s daughter
Alejandro Barrios – Latino
Jason Redford – Latino #2
Gregory Nassif St. John – Doctor
Allyssa Barley – Girl
William J. Harrison – Boy
Michael Aaron Milligan – Pal
Marcus Lyle Brown – Reporter
Amy Heidt – Lady with a Funny Eye
Maho Honda – Japanese Woman
Michael Lee Kimel – Japanese Man
Keith Paul Hunter – Officer
Neal Morgan – Townsperson
Trish Morgan – Police Station Secretary
Mark Salas – Ebbing Police Detective
Eleanor T. Threatt – Nurse
Wallace Sexton – Paramedic
Wonderful Cinema 